Supercritical Fluid Chromatography (SFC) is an important technique for separation in the pharmaceutical and chemical industry, where it is used both for analysis and for purification. To obtain acceptable separation performances and productivities for polar compounds a mobile phase consisting of both the main eluent CO2 and a polar co-solvent is needed. For compounds that are basic is also the presence of an amine additive required. Both the co-solvent and the additive may adsorb to the stationary phase and thereby compete with the solute for available adsorption sites. This competition will affect both retention and shape of the eluting profile for the solute. In this presentation, we will discuss these interactions between mobile and stationary phase and their effect on separation of pharmaceutical compounds.
Tid: 11 september klockan 14:30
Plats: Rum 3B 512 på Karlstads universitet
Seminariet är kostnadsfritt och ingen anmälan krävs.